Synthesis and biological evaluation of some new Aryl acid N'-(1H- indazole-3-carbonyl)-hydrazide derivatives

Recent drug discovery efforts are highly focused towards design and synthesis of small molecules of protein kinase C-β/AKt inhibitiors. 2 A wide ranges of heterocyclic ring systems has been studied for the development of novel chemical entities as lead molecules in the drug discovery paradigm. Indazole derivatives are one of the privileged structural fragments in medicinal chemistry having broad spectrum of potent pharmacological activities including anti-inflammatory, anti-tumor, or HIV protease inhibition. Numerous compounds containing Indazole moiety have been shown to exhibit estrogen receptor, antifungal, antibacterial activity. Among the important heterocycles, many of the natural and synthetic Indazole–based heterocycles with diverse mechanism of action have been reported as lead anticancer, 9 5-HT2, 5-HT3 and 5-HT4 receptor antagonisms. 10-13